The world is flat, make that flatter, compared to just a couple of decades ago. That has both positive and negative implications when it comes to managing disease and care on a global level.

With only a year to go until Britain leaves the EU, a mounting backlog of unresolved problems is causing business to take evasive action — despite government attempts to buy more time with a transition deal.

IBM has unveiled what it claims is the world’s smallest computer — the size of a grain of salt. The computer will cost less than $0.10 to manufacture, and is intended for logistics applications.

It’s the kind of bad news best served with a stiff drink: the price of standard supermarket wines such as prosecco and pinot grigio could rise by up to 30 percent this year as the impact of 2017’s disastrous harvest is felt on the high street.

It began in December, with CVS’s proposed $69bn buyout of insurer Aetna. In January, three more corporate behemoths — Amazon, JPMorgan Chase and Berkshire Hathaway — said they were forming a joint venture aimed at reducing health care costs and improving outcomes for their combined 1 million or so employees.